Leukaemias

Leukaemia is a cancer of the blood immune system, cells are called leukocytes or white cells

  • 1.1 Acute Lymphoblastic Leukaemia (ALL)
  • 1.2 Acute Myelogenous Leukaemia (AML)
  • 1.3 Acute Biphenotypic Leukaemia
  • 1.4 Acute Undifferentiated Leukaemia
  • 1.5 Chronic Lymphocytic Leukaemia (CLL)
  • 1.6 Chronic Myelogenous Leukaemia (CML)
  • 1.7 Juvenile Chronic Myelogenous Leukaemia (JCML)
  • 1.8 Juvenile Myelomonocytic Leukaemia (JMML)

 

Myelodysplastic Syndromes

Myelodysplastic Syndromes are also called pre-leukaemia

  • 2.1 Refractory Anaemia
  • 2.2 Refractory Anaemia with Ringed Sideroblasts (Sideroblastic anemia)
  • 2.3 Refractory Anaemia with Excess Blasts
  • 2.4 Refractory Anaemia with Excess Blasts in Transformation
  • 2.5 Chronic Myelomonocytic Leukaemia (CMML)

 

Lymphoma

Lymphoma is a cancer of the leukocytes that circulate in the blood and lymph vessels

  • 3.1 Hodgkin's Lymphoma
  • 3.2 Non-Hodgkin's Lymphoma (Burkitt's Lymphoma)

 

Transplants for Inherited Disorders

Transplants for Inherited Disorders of the Immune System & Other Organs

  • 4.1 Cartilage-Hair Hypoplasia
  • 4.2 Erythropoietic Porphyria
  • 4.3 Hermansky-Pudlak Syndrome
  • 4.4 Pearson's Syndrome
  • 4.5 Shwachman-Diamond Syndrome
  • 4.6 Systemic Mastocytosis

 

Transplants for Inherited Metabolic Disorders

Transplants for Inherited Metabolic Disorders

Mucopolysaccharidosis (MPS) Storage Diseases

  • 5.1 Hurler Syndrome (MPS-IH)
  • 5.2 Scheie Syndrome (MPS-IS)
  • 5.3 Hunter Syndrome (MPS-II)
  • 5.4 Sanfilippo Syndrome (MPS-III)
  • 5.5 Morquio Syndrome (MPS-IV)
  • 5.6 Maroteaux-Lamy Syndrome (MPS-VI)
  • 5.7 Sly Syndrome (MPS-VII) (beta-glucuronidase deficiency)
  • 5.8 Mucolipidosis II (I-cell Disease)

Leukodystrophy Disorders

  • 5.10 Adrenoleukodystrophy (ALD)
  • 5.11 Krabbe Disease(Globoid Cell Leukodystrophy)
  • 5.12 Metachromatic Leukodystrophy
  • 5.13 Pelizaeus-Merzbacher Disease

Lysosomal Storage Diseases

  • 5.14 Niemann-Pick Disease
  • 5.15 Sandhoff Disease
  • 5.16 Wolman Disease

Other Inherited Metabolic Disorders

  • 5.17 Lesch-Nyhan Syndrome
  • 5.18 Osteopetrosis

Other Disorders of Blood Cell Proliferation

Anaemias are deficiencies or malformations of red cells

  • 6.1 Aplastic Anaemia
  • 6.2 Fanconi Anaemia (The first cord blood transplant in 1988 was for FA, an inherited disorder)
  • 6.3 Congenital Dyserythropoietic Anaemia
  • 6.4 Paroxysmal Nocturnal Hemoglobinuria (PNH)

Inherited Red Cell Abnormalities. Red cells contain haemoglobin and carry oxygen to the body

  • 6.5 Sickle Cell Disease
  • 6.6 Beta Thalassemia Major (aka Cooley's Anaemia)
  • 6.7 Diamond-Blackfan Anaemia
  • 6.8 Pure Red Cell Aplasia

Inherited Platelet Abnormalities. Platelets are blood cells needed for clotting

  • 6.9 Amegakaryocytosis / Congenital Thrombocytopenia
  • 6.10 Glanzmann Thrombasthenia

Inherited Immune System Disorders: Severe Combined Immunodeficiency

  • 6.11 SCID with Adenosine Deaminase Deficiency (ADA-SCID)
  • 6.12 SCID which is X-linked
  • 6.13 SCID with absence of T & B Cells
  • 6.14 SCID with absence of T Cells, Normal B Cells
  • 6.15 Omenn Syndrome

Inherited Immune System Disorders: Neutropenias

  • 6.16 Infantile Genetic Agranulocytosis (Kostmann Syndrome)
  • 6.17 Myelokathexis

Inherited Immune System Disorders: Other

  • 6.18 Ataxia-Telangiectasia
  • 6.19 Bare Lymphocyte Syndrome
  • 6.20 Common Variable Immunodeficiency
  • 6.21 DiGeorge Syndrome
  • 6.22 Haemophagocytic lymphohistiocytosis
  • 6.23 Leukocyte Adhesion Deficiency
  • 6.24 Lymphoproliferative Disorders
  • 6.25 Lymphoproliferative Disorder, X-linked (Susceptibility to Epstein-Barr virus)
  • 6.26 Wiskott-Aldrich Syndrome

Myeloproliferative Disorders

  • 6.27 Acute Myelofibrosis
  • 6.28 Agnogenic Myeloid Metaplasia (Myelofibrosis)
  • 6.29 Polycythemia Vera
  • 6.30 Essential Thrombocythemia

Phagocyte Disorders - These are immune system cells that engulf and kill foreign organisms

  • 6.31 Chediak-Higashi Syndrome
  • 6.32 Chronic Granulomatous Disease
  • 6.33 Neutrophil Actin Deficiency
  • 6.34 Reticular Dysgenesis

Bone Marrow Cancers

  • 6.35 Multiple Myeloma
  • 6.36 Plasma Cell Leukaemia
  • 6.37 Waldenstrom's Macroglobulinemia Agnogenic Myeloid Metaplasia (Myelofibrosis)

 

Solid Tumours

Solid tumors not originating in the blood or immune system

  • 7.1 Neuroblastoma
  • 7.2 Medulloblastoma
  • 7.3 Retinoblastoma

 

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